Replicated analysis of the genetic architecture of quantitative traits in two wild great tit populations.
Identifieur interne : 002891 ( Main/Exploration ); précédent : 002890; suivant : 002892Replicated analysis of the genetic architecture of quantitative traits in two wild great tit populations.
Auteurs : Anna W. Santure [Nouvelle-Zélande] ; Jocelyn Poissant [Royaume-Uni] ; Isabelle De Cauwer [Royaume-Uni] ; Kees Van Oers [Pays-Bas] ; Matthew R. Robinson [Royaume-Uni] ; John L. Quinn [Irlande (pays)] ; Martien A M. Groenen [Pays-Bas] ; Marcel E. Visser [Pays-Bas] ; Ben C. Sheldon [Royaume-Uni] ; Jon Slate [Royaume-Uni]Source :
- Molecular ecology [ 1365-294X ] ; 2015.
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Abstract
Currently, there is much debate on the genetic architecture of quantitative traits in wild populations. Is trait variation influenced by many genes of small effect or by a few genes of major effect? Where is additive genetic variation located in the genome? Do the same loci cause similar phenotypic variation in different populations? Great tits (Parus major) have been studied extensively in long-term studies across Europe and consequently are considered an ecological 'model organism'. Recently, genomic resources have been developed for the great tit, including a custom SNP chip and genetic linkage map. In this study, we used a suite of approaches to investigate the genetic architecture of eight quantitative traits in two long-term study populations of great tits--one in the Netherlands and the other in the United Kingdom. Overall, we found little evidence for the presence of genes of large effects in either population. Instead, traits appeared to be influenced by many genes of small effect, with conservative estimates of the number of contributing loci ranging from 31 to 310. Despite concordance between population-specific heritabilities, we found no evidence for the presence of loci having similar effects in both populations. While population-specific genetic architectures are possible, an undetected shared architecture cannot be rejected because of limited power to map loci of small and moderate effects. This study is one of few examples of genetic architecture analysis in replicated wild populations and highlights some of the challenges and limitations researchers will face when attempting similar molecular quantitative genetic studies in free-living populations.
DOI: 10.1111/mec.13452
PubMed: 26661500
Affiliations:
- Irlande (pays), Nouvelle-Zélande, Pays-Bas, Royaume-Uni
- Angleterre, Gueldre (province), Oxfordshire
- Oxford, Wageningue
- Université d'Oxford, Université de Wageningue
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Santure</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, University of Auckland, Auckland, 1010, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>School of Biological Sciences, University of Auckland, Auckland, 1010</wicri:regionArea><wicri:noRegion>1010</wicri:noRegion></affiliation></author><author><name sortKey="Poissant, Jocelyn" sort="Poissant, Jocelyn" uniqKey="Poissant J" first="Jocelyn" last="Poissant">Jocelyn Poissant</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN</wicri:regionArea><wicri:noRegion>S10 2TN</wicri:noRegion></affiliation></author><author><name sortKey="De Cauwer, Isabelle" sort="De Cauwer, Isabelle" uniqKey="De Cauwer I" first="Isabelle" last="De Cauwer">Isabelle De Cauwer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN</wicri:regionArea><wicri:noRegion>S10 2TN</wicri:noRegion></affiliation></author><author><name sortKey="Van Oers, Kees" sort="Van Oers, Kees" uniqKey="Van Oers K" first="Kees" last="Van Oers">Kees Van Oers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), 6708 PB, Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), 6708 PB, Wageningen</wicri:regionArea><wicri:noRegion>Wageningen</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Matthew R" sort="Robinson, Matthew R" uniqKey="Robinson M" first="Matthew R" last="Robinson">Matthew R. Robinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN</wicri:regionArea><wicri:noRegion>S10 2TN</wicri:noRegion></affiliation></author><author><name sortKey="Quinn, John L" sort="Quinn, John L" uniqKey="Quinn J" first="John L" last="Quinn">John L. Quinn</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological, Earth and Environmental Sciences, University College Cork, Distillery Fields, North Mall, Cork, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Biological, Earth and Environmental Sciences, University College Cork, Distillery Fields, North Mall, Cork</wicri:regionArea><wicri:noRegion>Cork</wicri:noRegion></affiliation></author><author><name sortKey="Groenen, Martien A M" sort="Groenen, Martien A M" uniqKey="Groenen M" first="Martien A M" last="Groenen">Martien A M. Groenen</name><affiliation wicri:level="4"><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University, De Elst 1, Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Animal Breeding and Genomics Centre, Wageningen University, De Elst 1, Wageningen</wicri:regionArea><orgName type="university">Université de Wageningue</orgName><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName></affiliation></author><author><name sortKey="Visser, Marcel E" sort="Visser, Marcel E" uniqKey="Visser M" first="Marcel E" last="Visser">Marcel E. Visser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), 6708 PB, Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), 6708 PB, Wageningen</wicri:regionArea><wicri:noRegion>Wageningen</wicri:noRegion></affiliation></author><author><name sortKey="Sheldon, Ben C" sort="Sheldon, Ben C" uniqKey="Sheldon B" first="Ben C" last="Sheldon">Ben C. Sheldon</name><affiliation wicri:level="4"><nlm:affiliation>Department of Zoology, Edward Grey Institute, University of Oxford, Oxford, OX1 3PS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Zoology, Edward Grey Institute, University of Oxford, Oxford, OX1 3PS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Slate, Jon" sort="Slate, Jon" uniqKey="Slate J" first="Jon" last="Slate">Jon Slate</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN</wicri:regionArea><wicri:noRegion>S10 2TN</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular ecology</title><idno type="eISSN">1365-294X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chromosome Mapping</term><term>Genetic Association Studies</term><term>Genetics, Population</term><term>Genotype</term><term>Netherlands</term><term>Passeriformes (genetics)</term><term>Phenotype</term><term>Polymorphism, Single Nucleotide</term><term>Quantitative Trait Loci</term><term>United Kingdom</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cartographie chromosomique</term><term>Génotype</term><term>Génétique des populations</term><term>Locus de caractère quantitatif</term><term>Passeriformes (génétique)</term><term>Pays-Bas</term><term>Phénotype</term><term>Polymorphisme de nucléotide simple</term><term>Royaume-Uni</term><term>Études d'associations génétiques</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Passeriformes</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Passeriformes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chromosome Mapping</term><term>Genetic Association Studies</term><term>Genetics, Population</term><term>Genotype</term><term>Netherlands</term><term>Phenotype</term><term>Polymorphism, Single Nucleotide</term><term>Quantitative Trait Loci</term><term>United Kingdom</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cartographie chromosomique</term><term>Génotype</term><term>Génétique des populations</term><term>Locus de caractère quantitatif</term><term>Pays-Bas</term><term>Phénotype</term><term>Polymorphisme de nucléotide simple</term><term>Royaume-Uni</term><term>Études d'associations génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Currently, there is much debate on the genetic architecture of quantitative traits in wild populations. Is trait variation influenced by many genes of small effect or by a few genes of major effect? Where is additive genetic variation located in the genome? Do the same loci cause similar phenotypic variation in different populations? Great tits (Parus major) have been studied extensively in long-term studies across Europe and consequently are considered an ecological 'model organism'. Recently, genomic resources have been developed for the great tit, including a custom SNP chip and genetic linkage map. In this study, we used a suite of approaches to investigate the genetic architecture of eight quantitative traits in two long-term study populations of great tits--one in the Netherlands and the other in the United Kingdom. Overall, we found little evidence for the presence of genes of large effects in either population. Instead, traits appeared to be influenced by many genes of small effect, with conservative estimates of the number of contributing loci ranging from 31 to 310. Despite concordance between population-specific heritabilities, we found no evidence for the presence of loci having similar effects in both populations. While population-specific genetic architectures are possible, an undetected shared architecture cannot be rejected because of limited power to map loci of small and moderate effects. This study is one of few examples of genetic architecture analysis in replicated wild populations and highlights some of the challenges and limitations researchers will face when attempting similar molecular quantitative genetic studies in free-living populations.</div></front></TEI><affiliations><list><country><li>Irlande (pays)</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Gueldre (province)</li><li>Oxfordshire</li></region><settlement><li>Oxford</li><li>Wageningue</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Wageningue</li></orgName></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Santure, Anna W" sort="Santure, Anna W" uniqKey="Santure A" first="Anna W" last="Santure">Anna W. Santure</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Poissant, Jocelyn" sort="Poissant, Jocelyn" uniqKey="Poissant J" first="Jocelyn" last="Poissant">Jocelyn Poissant</name></noRegion><name sortKey="De Cauwer, Isabelle" sort="De Cauwer, Isabelle" uniqKey="De Cauwer I" first="Isabelle" last="De Cauwer">Isabelle De Cauwer</name><name sortKey="Robinson, Matthew R" sort="Robinson, Matthew R" uniqKey="Robinson M" first="Matthew R" last="Robinson">Matthew R. Robinson</name><name sortKey="Sheldon, Ben C" sort="Sheldon, Ben C" uniqKey="Sheldon B" first="Ben C" last="Sheldon">Ben C. Sheldon</name><name sortKey="Slate, Jon" sort="Slate, Jon" uniqKey="Slate J" first="Jon" last="Slate">Jon Slate</name></country><country name="Pays-Bas"><noRegion><name sortKey="Van Oers, Kees" sort="Van Oers, Kees" uniqKey="Van Oers K" first="Kees" last="Van Oers">Kees Van Oers</name></noRegion><name sortKey="Groenen, Martien A M" sort="Groenen, Martien A M" uniqKey="Groenen M" first="Martien A M" last="Groenen">Martien A M. Groenen</name><name sortKey="Visser, Marcel E" sort="Visser, Marcel E" uniqKey="Visser M" first="Marcel E" last="Visser">Marcel E. Visser</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Quinn, John L" sort="Quinn, John L" uniqKey="Quinn J" first="John L" last="Quinn">John L. Quinn</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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